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Urethane

Application instruction:

Use

By-effects

Contraindications

Use in veterinary science

Storage conditions

Urethane - ethyl ether of carbamic acid.

Urethane is produced Формула Уретана in the form of powder - the colourless crystals cooling, slightly salty on taste. Has no smell, it is easily dissolved in alcohol and water, forming colourless solution.

Use of Urethane in medicine

Has the calming and somnolent effect on the person Uretan. As a rule, the dream comes twenty minutes later and proceeds from four to eight hours.

According to reviews Urethane is easily transferred by patients, however it is seldom applied as a hypnagogue because of a variable effect and low activity in comparison with other somnolent drugs.

In the nursery the practician Uretan use as anticonvulsant and a calmative at whooping cough.

As a rule, for adults the dosage makes 1-2 g on reception, but no more than 4 g a day. To children appoint drug in a dosage of 0,5-1 g to reception, but no more than 1,5 g a day.

Use drug also for treatment of chronic myeloid leukoses.

For this purpose appoint inside on 1 g of drug from two to four times a day for one month. On a course of treatment from 60 to 120 g of drug leave on average. In one week after the beginning of administration of drug the quantity of leukocytes and their unripe forms decreases, and in two weeks the liver and a spleen decrease in sizes. Remission continues usually before half a year.

Urethane by-effects

According to reviews Urethane at intake can cause the dispepsichesky phenomena. That to avoid them, recommend:

to accept drug in capsules and to wash down them with alkaline water;
to enter into a vein 40% glucose solution;
to increase daily dosages of ascorbic acid.

At bad portability of drug it is allowed to do intramuscular injections: 25% solution on 4 ml or 50% solution on 2 ml three times a day. In certain cases intramuscular use is even more preferable.

Contraindications

Urethane is contraindicated Уретан в виде порошка at the acute and chronic leukoses proceeding with a generalized hyperadenosis and with an essential splenomegaly and also at subleukemic or aleukemic forms. It is forbidden to use drug at the expressed atherosclerosis.

Use of Urethane in veterinary science

In small dosages Urethane possesses the calming and somnolent action. In big dosages it causes an anesthesia with small deviations from cardiovascular system and breath in dogs and rabbits, without stage of motive excitement.

Does not affect horses and cattle even in big dosages.

Urethane is preferential applied as narcotic and a hypnagogue to laboratory animals (rabbits, mice, rats).

Apply to goats, sheep and dogs in a combination with magnesium sulfate in a dosage of 0,25 g of powder on one kg of weight of an animal to an anesthesia. In this case add the calculated drug dosage to solution of magnesium sulfate of 10%, wait for full dissolution and enter intravenously.

Intramusculary enter the following dosages:

To cats – 0,5-0,75 g;
To dogs – 0,3-0,5 g;
To hens – 1-2 g.

Intravenous dosages of Urethane make:

For dogs – 0,3 g;
For goats and sheep – on 0,25 g.

Storage conditions

Store powder in the dry dark place, in carefully corked glass jars.

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