Coldrex

Coldrex – the drug with antiedematous, expectorant, analgeziruyushchy and febrifugal action applied to a symptomatic treatment of flu and catarrhal diseases.

Form of release and structure

Coldrex is produced in the form of tablets: kapsulovidny, two-layer, orange-white, the orange layer can contain white inclusions, with a stamping of "Coldrex" on one of the parties (on 5, 6, 8, 12 pieces in blisters, on 1 or 2 blisters in a cardboard pack).

Active agents are a part of 1 tablet:

• Caffeine – 25 mg;
• Paracetamol – 500 mg;
• Terpin hydrate – 20 mg;
• Phenylephrinum hydrochloride – 5 mg;
• Vitamin C (ascorbic acid) – 30 mg.

Auxiliary components: talc, soluble and corn starch, dye, povidone, potassium sorbate, stearic acid, sodium lauryl sulfate.

Indications to use

Coldrex is appointed for elimination of symptoms of flu and catarrhal diseases, such as:

• Headache;
• The increased temperature;
• Fever;
• Feeling of a congestion of a nose;
• Pharyngalgia and nasal bosoms;
• Muscular and joint pains.

Contraindications

• Diseases of circulatory system;
• Arterial hypertension;
• Heavy functional disturbances of kidneys or liver;
• Diabetes mellitus;
• Thyrotoxicosis;
• Genetic absence glyukozo-6-fosfatdegidrogenazy;
• Simultaneous use with other medicines containing paracetamol;
• Hypersensitivity to drug components.

The feeding and pregnant women, and also children up to 6 years can accept Coldrex only after medical consultation.

Route of administration and dosage

Coldrex is accepted inside.

The mode of dosing is defined by age:

• Adults and children of 12 years – on 2 tablets;
• Children of 6-12 years – on 1 tablet.

Frequency rate of reception – to 4 times a day.

The recommended dose should not be exceeded.

Without consultation with the doctor it is not recommended to accept Coldrex longer than 5 days. At preservation of symptoms it is necessary to see a doctor.

Side effects

At use in the recommended doses Coldrex, as a rule, is transferred well.

The possible side effects arising during administration of drug are defined by the components which are its part.

Paracetamol can cause the following disturbances:

• Sometimes: allergic reactions (Quincke's disease, small tortoiseshell, skin rash);
• Seldom: disturbances of a picture of blood.

At long use of the doses exceeding recommended development of hepatotoxic and nephrotoxic action is possible.

Use of Phenylephrinum can lead to emergence of disturbances from some systems of an organism:

• Alimentary system: nausea;
• Cardiovascular system: headache, insignificant increase in arterial pressure; seldom – heartbeat (after drug withdrawal symptoms pass).

Special instructions

The excess use of coffee or tea during therapy can lead to development of irritability and nervous tension.

To avoid toxic damage of a liver by the patient it is necessary to abstain from alcohol intake. At an alcoholism reception of Coldrex is not recommended.

Medicinal interaction

At simultaneous use of Coldrex with some medicines there can be undesirable effects:

• Dipheninum, barbiturates, rifampicin, carbamazepine, zidovudine and other inductors of microsomal enzymes of a liver: increase in risk of development of a hepatotoxic action;
• Domperidon, Metoclopramidum: increase in speed of absorption of paracetamol;
• Colestyraminum: reduction in the rate of absorption of paracetamol.

Simultaneous use of Coldrex with beta adrenoblockers, tricyclic antidepressants and monoamine oxidase inhibitors is not recommended. Between administrations of drugs it is necessary to observe a break not less than 14 days.

Terms and storage conditions

To store in the place, dry, unavailable to children.

Period of validity – 4 years.