Oletetrinum
Application instruction:
Oletetrinum – the antibacterial combined drug with a broad spectrum of activity.
Form of release and structure
Oletetrinum is released in the form of tablets, coated (in blister strip packagings on 10 pieces, on 1 or 2 packagings in a cardboard pack; in polymeric banks on 25 pieces, after 1 bank in a cardboard pack).
Active agents are a part of 1 tablet:
- Oleandomycinum phosphate (mg tablets 125/250) – 47,5/95 mg;
- Tetracycline (mg tablets 125/250) – 77,5/155 mg.
Auxiliary components: calcium stearate, medical talc, potato starch.
Indications to use
Oletetrinum is appointed for treatment of the diseases caused by the microorganisms showing sensitivity to effect of active agents including purulent infections of skin and soft tissues, osteomyelitis, pneumonia, meningitis, pharyngitis, sinusitis, tonsillitis, bronchitis, a bronchoectatic disease, average otitis, cholecystitis, prostatitis, infections of urinogenital bodies, pyelonephritis, an endometritis, cystitis, erysipelatous inflammations, purulent gonorrhea, a brucellosis, a tularemia.
Contraindications
- Liver/renal failure;
- Mycoses;
- Leukopenia;
- Age up to 8 years;
- Pregnancy and period of a lactation;
- Hypersensitivity to drug components.
Route of administration and dosage
Oletetrinum is accepted inside, washing down with water, it is more preferable – after meal.
The recommended dosing mode:
- Children of 8 years: 20-30 mg/kg a day; frequency rate of use – 4 times a day;
- Adults: 4 times a day on 250 mg; as much as possible – 2000 mg a day.
Course duration – from 7 to 10 days (is defined by weight of an infection).
Side effects
During treatment development of side effects in the form of nausea, vomiting, a loss of appetite, abdominal pains, locks or diarrhea, a dysphagy, a glossitis, an esophagitis, allergic reactions (an itch, skin rash, an eosinophilia) is possible.
Long therapy can lead to emergence of such disturbances as intestinal dysbacteriosis, increase in activity of "hepatic" transaminases, candidiasis, a neutropenia, development of a lack of vitamins of group B and K, thrombocytopenia, hemolitic anemia, a photosensitization, a giperkreatininemiya, a hyperbilirubinemia, an azotemia.
Special instructions
During development of teeth in children use of Oletetrinum can lead to change of their color (has irreversible character).
Medicinal interaction
At the combined use of Oletetrinum with some drugs there can be following effects:
- Bactericidal medicines: decrease in their efficiency;
- Vitamin A: increase in probability of developing of intracranial hypertensia;
- Drugs and foodstuff with the content of salts of magnesium, calcium, aluminum, iron (iron preparations, antacids, dairy products and milk): reduction of absorption of Oletetrinum;
- Metoksifluran: increase in its nephrotoxicity;
- Oral contraceptives: decrease in their efficiency and increase in risk of development of uterine bleedings.
Terms and storage conditions
To store in the place, unavailable to children, at a temperature up to 25 °C.
Period of validity – 2 years.
Name of drug
Price
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