Pyrazinamidum

Pyrazinamidum – the synthetic antitubercular drug depending on sensitivity of a microorganism and concentration having bactericidal or bacteriostatic effect.

Form of release and structure

Dosage form – tablets (on 100 or 1000 pieces in packaging).

Active ingredient: Pyrazinamidum, its contents in 1 tablet makes 500 or 750 mg.

Additional components: silicon dioxide colloid, gelatin, sodium is glikolit starch, magnesium by stearate, starch, talc.

Indications to use

Pyrazinamidum – choice drug for treatment of tuberculosis, especially for the first time the revealed destructive pulmonary tuberculosis proceeding with disturbance of structure of pulmonary fabric.

Besides, Pyrazinamidum can be applied to therapy of the following diseases (in a combination with other antituberculous remedies):

• Tuberculosis of bones;
• Tubercular meningitis;
• Urinogenital tuberculosis;
• Pulmonary tuberculosis.

Contraindications

Absolute:

• Liver diseases;
• Hyperuricemia;
• Gout;
• Period of pregnancy and lactation;
• Hypersensitivity to drug components.

Route of administration and dosage

Pyrazinamidum should be accepted inside during food or after meal of 1 times a day, it is preferable – during a breakfast. It is necessary to swallow of tablets entirely and to wash down with enough water.

The adult appoint 25-30 mg/kg/days: patients with body weight it is more than 50 kg – 2000 mg, with body weight it is less than 50 mg – 1500 mg.

The highest admissible dose – 2500 mg/days, for elderly people – 15 mg/kg (at advanced and senile age it is reasonable to appoint drug every other day).

In case of unsatisfactory portability of drug the daily dose is divided into 2-3 receptions.

To children appoint 15-30 mg/kg/days, but no more than 1500 mg.

Pyrazinamidum is applied in a combination with aminoglycosides (streptomycin or Kanamycinum in a dose of 15 mg/kg), rifampicin (10 mg/kg), an isoniazid (10 mg/kg).

Duration of a course of therapy makes 3 months.

Side effects

• From digestive tract: metal smack in a mouth, lack of appetite, diarrhea, epigastric pains, nausea, vomiting, an abnormal liver function; at prolonged use – toxic action on a liver;
• From the central nervous system: at prolonged use – a hyperexcitability, a sleep disorder, a headache, weakness, a depression, dizziness; in some cases – hallucinations, confusion of consciousness, a spasm;
• Allergic reactions: dermatitis, eosinophilia, fever, etc.;
• Others: an arthralgia, a photosensitization, a hyperuricemia, an exacerbation of gout, a delay in an organism of uric acid, joint pains of gouty character.

Special instructions

Pyrazinamidum can promote a delay in an organism of uric acid and to emergence of joint pains of gouty character therefore at least 1 time a month it is necessary to carry out control of content of uric acid to blood and activities of hepatic transaminases.

Periodically during treatment for control of function of a liver it is necessary to carry out biochemical tests (a research of glutaminoshavelevokisly transaminase of blood serum, determination of level of bilirubin, a thymol turbidity test, etc.). In case of identification of changes of a functional condition of a liver drug needs to be cancelled.

For reduction of toxic action of Pyrazinamidum use _{of B4 vitamin}, glucose, methionine is recommended.

Medicinal interaction

Pyrazinamidum is applied in a combination with other antituberculous remedies, in particular at chronic destructive forms of a disease it is at the same time recommended to apply Ethambutolum (portability improves) or rifampicin ( the effect is more expressed).

At combined use of rifampicin the risk of development of a hepatotoxic action increases.

At co-administration of a probenetsid decrease in removal from an organism and, as a result, strengthening of toxic reactions is possible.

Terms and storage conditions

To store in the unavailable to children, protected from light and moisture place at a temperature up to 25 ºС.

Period of validity – 3 years.