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Follicular dyskeratosis


To Darya a disease (a synonym a follicular dyskeratosis) — the chronic, rather rare skin disease which is characterized by emergence of cone-shaped small knots from 2 to 5 mm in the diameter of yellow-brown or brown color.

Symptoms of the Follicular dyskeratosis:

On skin there are dense giperkeratotichesky cone-shaped small knots size from a pin head to lentil covered with a grayish-brown or yellowish-brown crust under which it is possible to find a funneled form deepening (an expanded opening of the mouth of a follicle). Localization of small knots various: on a pilar part of the head, a face, especially in temples and nasolabial folds, auricles, on a neck, and also sites of skin with the strengthened sweating (in axillary, femoral and scrotal areas); skin of a stomach, sacral area, a back of the hand and feet, and sometimes palms and soles, a mucous membrane of a mouth is surprised.
On many sites of skin, especially with the strengthened sweating, also not follicular small knots meet; the last can merge in plaques, there are papillomatous growths in the form of vegetation. On a pilar part of the head process proceeds like dry seborrhea. On the back of brushes and feet there are densely sitting multiple small knots reminding flat warts; they can sometimes have an appearance of callosities with the central cave-in. Nails which become the opaque, covered longitudinal furrows also are sometimes involved in process.
Histopathology. Papillomatosis, acanthosis, existence of round little bodies (diskeratotichesky cells), grains and lacunas (intra epithelial cracks).
Giperkeratotichesky traffic jams both in grease and hair follicles, and out of them, for example in palms and soles, on mucous membranes.
Differentiate from a vegetans pemphigus at which there is no damage of palms and soles. Initial forms of a disease to Darya can be similar to a giperkeratotichesky nevus, however at the last the hyperkeratosis is more expressed.

Reasons of the Follicular dyskeratosis:

The etiology and pathogeny are not clear, at a part of patients the White's disease has family character. Men and women are ill, young people are more often. A current chronic with temporary remissions.

Treatment of the Follicular dyskeratosis:

Chronic ingestion of high doses of vitamin A. Polyvitamins. Separate elements give in to cryotherapy by liquid nitrogen, electrothermic coagulations. At vegetans growths recommend surgical treatment. Good results are yielded by dermabrasion. Apply the peeling ointments, a roentgenotherapy — Bukki's beams. Respect for personal hygiene for prevention of consecutive infection is necessary.

Drugs, drugs, tablets for treatment of the Follicular dyskeratosis:

  • Препарат Ретинола ацетат 3,44% мас р-р 10 мл.

    Retinolum acetate of 3,44% Mas solution of 10 ml

    The means influencing the alimentary system and metabolic processes.

    CJSC Lekhim-Kharkiv Ukraine

  • Препарат Неотигазон.


    Reparations of fabrics stimulator.

    F. Hoffmann-La Roche Ltd., (Hoffman-la Roche Ltd) Switzerland

  • Препарат Уродерм.


    Drug with antiinflammatory and keratolytic action for external use.

    CJSC FNPP Retinoidy Rossiya

  • Препарат Витамин А.

    Vitamin A

    Simple vitamin means.

    Minskinterkaps Unitary Enterprise Republic of Belarus

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